Commercial Low-Earth Orbit destinations (CLDs) are the next milestone in the development of commercial space transportation, but the legal responsibilities of spaceflight providers, personnel, and spaceflight participants (SFPs) on board are not easily discernible. This article describes the purpose and goals of CLDs; assesses current regulations enforced against private companies’ activities in space; and proposes different liability frameworks for application to CLD activity. Development of a comprehensive liability regime is crucial to promoting innovation in commercial space, while also protecting the safety interests of all personnel and participants on board.