This article discusses (1) the uptake of Online Dispute Resolution (ODR) by APEC economies and the reasons underlying it, (2) the prognosis for regional expansion of cross-border ODR, particularly for business-to-business (B2B) and business to consumer (B2C) disputes, (3) participation in the APEC ODR Framework by present and prospective regional ODR providers, and (4) the place of ODR in helping to promote increased cross-border trade.