This article studies the prima facie assessment by the Cairo Regional Centre for International Commercial Arbitration (CRCICA) of its jurisdiction, through the operation of Article 6 of its Arbitration Rules issued in 2011. It examines a number of cases filed between 2020 and 2022 where one or more of the parties submitted a request not to proceed with the arbitration to CRCICA for manifest lack of jurisdiction, showing the most common grounds for these requests and their outcomes.The study has shown the increase of multi-party and multi-contracts disputes filed before CRCICA in the last few years as well as the problems that arise from poorly drafted arbitration agreements.