Though dramatically different in terms of style and rhetoric on how to best lead the country, it remains to be seen how different United States trade policy between the current and former administration, and in particular President Biden’s use of Executive Orders to implement sanctions, will be used in shaping the global priorities of the United States. This article highlights the top countries facing the Department of Treasury’s Office of Foreign Assets Control (OFAC) activity under the new Presidency and what direct, and indirect, messages reveal themselves through these first actions by the Biden Administration.