The objective of this article is to reflect on the rise and decline of judicialization in international trade and investment regimes and explore the future of international economic dispute settlement. It makes three key arguments. First, the severe disjuncture between anticipated benefits of international dispute settlement and the actual costs imposed on states explains the emerging trend of dejudicialization in international economic law. Second, at least to some extent, dejudicialization is likely to be a staple feature of international economic law in the new era of deglobalization, climate crisis, and great power rivalry. Third, judicialization of international dispute settlement will not demise but substantial transformation is necessary to meet contemporary challenges.