The Covid-19 pandemic has deepened the existing gender inequalities. In particular, it has dealt a significant blow to women entrepreneurs, as it has magnified the pre-pandemic disadvantages women have faced in the economic, social, financial and regulatory ecosystems they operate in, particularly due to the nature and size of their businesses. The article outlines three main reasons that explain why women entrepreneurs have been disproportionately impacted during this health pandemic. It then explores how trade agreements can help women overcome the barriers that impede their entrepreneurial potential and help their businesses sustain the pandemic-inflicted market disruptions.